Our expertise in Transition Metal Catalysis
We focus on the specific challenges of scale-up and large-scale TMC processes. Our equipment is designed to meet the special needs of those reactions. Our R&D efforts address all specific TMC issues, such as catalyst activity, handling and sourcing, as well as noble metal removal and catalyst recycling. We have extensive expertise in carbonylation, catalytic coupling reactions and asymmetric hydrogenation. Moreover, we collaborate with the leading technology providers in these fields. As the only independent provider of TMC worldwide, we always have a complete solution to your needs, including issues such as IP and reliable access to the respective catalyst.
Access to Unique Molecular Structures (Suzuki Coupling)
Low Temperature Synthesis of Boronic Acid and Palladium Catalyzed Coupling Reaction
Benefits with TMC by RohnerChem: Fast development, reliable and safe process, high quality.
Goal: To produce the 5-aryl-indole on multikilogramm scale.
- The challenge was the synthesis of the aryl boronic acid with an electrophilic group and the Suzuki coupling.
- The whole development including the production on pilot plant scale was carried out in less than 4 months.
- Both starting materials, 4-bromo-benzonitrile and 5-bromo-indole are standard products of RohnerChem.
- The lithiation of the bromo-benzonitrile was carried out at - 70 °C to avoid the attack of the BuLi on the nitrile group.
- The Suzuki coupling was carried out with 0.1 mol-% palladium catalyst.
- The palladium could be removed completely after the reaction (< 10 ppm).
Synthesis of Chiral Products
Asymmetric Hydrogenation under High Pressure
Benefit with TMC by RohnerChem: Sophisticated equipment, state of the art catalysis know how, fast development. The goal was the production of 400 kg of the chiral alcohol with an enantiomeric excess >98%.
The process was developed in collaboration with the technology provider Solvias. Solvias optimized the reaction conditions and the catalyst. RohnerChem was responsible for scale-up and safety investigation as well as the development of processing. Development and production of the 400 kg were successfully completed within two months. The reaction was carried out at 25 °C and at 20 bar. The quality of the starting material and the handling of the homogeneous catalyst were identified as the most critical factors.
Access to Special Benzoic Acid Derivatives
Benefit for Customer: Profound know how in carbonylation and access to facilities with CO handling capabilities. The goal was the production of several kilograms of an activated ester as an intermediate.
The palladium catalyzed carbonylation reaction was used for the synthesis of a sophisticated activated succinimidyl ester. The process including optimization, processing and removal of the palladium was developed within 2 months. The catalyst loading was optimized to a loading of s/c of 1000. The reaction was run under moderate conditions: 5 bar, 120 °C.